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Adalimumabe

Nome original: Adalimumab

Fonte atualizada
09 de junho de 2026
Versão coletada
25 de agosto de 2026

Compatibilidade

Compatível

Seguro, melhor opção

Resumo do nível

Produto seguro e/ou a amamentação é a melhor opção.

Leia o comentário completo: o nível resume o risco, mas não substitui contexto clínico, dose, idade do bebê ou orientação profissional.

Outros nomes
Αδαλιμουμάμπη, أداليموماب, Адалимумаб, 阿达木单抗, アダリムマブ, L04AB04
Marcas comerciais
Abrilada, Amgevita, Hadlima, Hulio, Humira, Humira (Хумира), Humira (修美乐), Hyrimoz… Ver todas as 12
Procedência
Dados editoriais
Tradução
Pendente de revisão
Grupo ATC
L04
Fonte
Abrir original

Leitura clínica

Comentário

Anticorpo monoclonal humano IgG1 contra o fator de necrose tumoral usado em doenças autoimunes como artrite reumatoide, artrite idiopática juvenil, espondilite anquilosante, artrite psoriásica, psoríase, hidradenite supurativa, doença de Crohn, colite ulcerosa e uveíte. Administração por via subcutânea semanal ou quinzenalmente. Se excreta no leite materno em quantidade clinicamente não significativa (Matro 2018, Fritzsche 2012, Ben-Horin 2010) e não se observaram problemas clínicos, infecciosos ou de desenvolvimento em bebês cujas mães a tomavam. (Palomino 2025, Bendaoud 2024, Membrive 2023, Matro 2018, Lund 2017, Dall'ara 2016, Julsgaard 2013, Fritzsche 2012, Mishkin 2006, Mahadevan 2006, Vesga 2005) Os níveis no plasma desses bebês foram indetectáveis ou muito baixos. (Julsgaard 2013, Fritzsche 2012) Por sua natureza proteica é inativada no trato gastrointestinal, não sendo absorvida, (biodisponibilidade oral praticamente nula), o que dificulta ou impede a passagem para o plasma do bebê que mama a partir do leite materno ingerido (Lactmed, Anderson 2021, Rademaker 2018, Götestam 2016, Witzel 2014, Butler 2014, Mervic 2014), exceto em prematuros e período neonatal imediato, em que pode haver maior permeabilidade intestinal (Sammaritano 2020). Possivelmente convenha evitar seu uso na primeira semana após o parto: pode haver passagem significativa de IgG para o leite até os primeiros 3-4 dias pós-parto. Esperar duas semanas após o parto antes de retomar o tratamento permite que os níveis plasmáticos do recém-nascido desçam dos anteriores intra-útero e também reduz ao mínimo a transmissão ao bebê. (Krysko 2023) Foi publicado um caso de neutropenia congênita precoce em um recém-nascido cuja mãe tomava adalimumab por uma doença de Crohn e isoniazida por uma tuberculose. (van den Broek 2018) Os fármacos anti-TNF reduzem os níveis de fator de necrose tumoral no leite materno (Sepiashvili 2025). Esta redução do TNF, que intervém na produção de leite, poderia aumentar o risco de insuficiência de amamentação. (Yan 2026) O fabricante (Amgen 2017, EMA 2010) considera seguro o uso desta medicação durante a amamentação. Numerosos especialistas e sociedades científicas de Reumatologia, Gastroenterologia e Dermatologia consideram de muito baixo risco e, portanto, compatível seu uso durante a amamentação. (Hale, Mahadevan 2025, Rüegg 2025, Torres 2023, Russell 2023, Owczarek 2020, Yeung 2020, Sammaritano 2020 e 2014, Lamb 2019, Mahadevan 2019 e 2013, Picardo 2019, Amin 2018, Nguyen 2016, Flint 2016, McConnell 2016, Gotestam 2016, Huang 2016 e 2014, Briggs 2015, Grunewald 2015, Damas 2015, van der Woude 2015 e 2010, Nielsen 2014, Witzel 2014, Butler 2014, Schulze 2014, Yarur 2013, Bae 2012, Fischer 2010). Pode consultar abaixo a informação destes produtos relacionados: Artrite Reumatoide (AR) Materna (Bastante seguro. Efeitos adversos leves ou pouco prováveis. Compatível em determinadas circunstâncias. Acompanhamento recomendado. Leia o Comentário.) Doença inflamatória intestinal (DII) materna (Bastante seguro. Efeitos adversos leves ou pouco prováveis. Compatível em determinadas circunstâncias. Acompanhamento recomendado. Leia o Comentário.)

Encontrabilidade

Outros nomes e marcas

Sinônimos e grafias 6
  • Αδαλιμουμάμπη
  • أداليموماب
  • Адалимумаб
  • 阿达木单抗
  • アダリムマブ
  • L04AB04
Marcas comerciais na fonte 12
  • Abrilada
  • Amgevita
  • Hadlima
  • Hulio
  • Humira
  • Humira (Хумира)
  • Humira (修美乐)
  • Hyrimoz
  • Idacio
  • Imraldi
  • Xilbrilada
  • Yuflyma

Dados da fonte

Farmacocinética

VariávelValorUnidade
Biodisp. oral0%
Peso Molecular148.000daltons
Unión proteínas0%
Vd0,07 - 0,09l/Kg
Tmax131horas
T½360 (240 - 480)horas
Índice L/P0,01-
Dosis Teórica0,00465mg/Kg/d
Dosis Relativa0,7%

Rastreabilidade

Bibliografia

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  57. Mishkin DS, Van Deinse W, Becker JM, Farraye FA. Successful use of adalimumab (Humira) for Crohn's disease in pregnancy. Inflamm Bowel Dis. 2006 Aug;12(8):827-8. No abstract available. Resumen
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Escala de compatibilidade

Como ler os níveis

  1. CompatívelSeguro, melhor opção
  2. Compatibilidade provávelBastante seguro
  3. Compatibilidade limitadaPouco seguro
  4. IncompatívelMuito inseguro

A cor ajuda a localizar o nível; o símbolo, o rótulo e o texto trazem a mesma informação.