Leitura clínica
Comentário
Antidepressivo ISRS com ações e usos similares aos da fluoxetina. Administração oral em uma dose diária. Se excreta no leite materno em pequena quantidade, embora ocasionalmente com uma dose relativa superior a 10%. (Pogliani 2019, Schoretsanitis 2019, Weisskopf 2017, Rampono 2000, Schmidt 2000, Jensen 1997, Spigset 1997) Os níveis no plasma dos bebês cujas mães o tomam são indetectáveis ou muito baixos. (Berle 2004, Heikkinen 2002, Nordeng 2001, Rampono 2000). Embora haja algum caso isolado de alterações transitórias do sono, irritabilidade ou cólicas (Kronenfeld 2018, Schmidt 2000, Lee 2004), não se observaram problemas a curto nem a longo prazo na maioria de bebês cujas mães o tomavam. (Werremeyer 2009, Berle 2004, Hendrick 2003, Rampono 2000, Jensen 1997) Pode haver problemas de adaptação transitórios durante o período neonatal imediato, como a síndrome de descontinuação de antidepressivos, em recém-nascidos a termo ou prematuros que nascem com níveis plasmáticos altos porque suas mães tomam citalopram durante a gravidez. (Erol 2017, Kieviet 2015, Franssen 2006, Nordeng 2001) Pode ocorrer galactorreia associada ou não a hiperprolactinemia. (Türkoğlu 2016, Trenque 2011, Koch 2011, Wessels 2006, González 2001) Diversas sociedades médicas e consensos de especialistas consideram seguro o uso desta medicação durante a amamentação. (Hale, Lactmed, Uguz 2021, Rubin 2004, Wisner 2002) São preferíveis alternativas conhecidas mais seguras durante a amamentação, especialmente durante o período neonatal e em caso de prematuridade. (Weisskopf 2017, Sriraman 2015, Larsen 2015, Sachs 2013, Rowe 2013, Berle 2011, Patil 2011, Davanzo 2010, Lanza 2009, ABM 2008, Weissman 2004, Gjerdingen 2003, Nordeng 2001) As mulheres com depressão durante a gravidez precisam de mais apoio à amamentação por terem mais risco de problemas e cessação precoce da amamentação. (Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012) Pode consultar abaixo a informação deste produto relacionado: Depressão Materna (Produto seguro e/ou a amamentação é a melhor opção.)
Encontrabilidade
Outros nomes e marcas
Sinônimos e grafias 8
- Hidrobromuro de citalopram
- Hidrocloruro de citalopram. Nitalapram
- Σιταλοπράμη
- سيتالوبرام
- Циталопрама
- 西酞普兰
- シタロプラム
- N06AB04
Marcas comerciais na fonte 33
- CTP
- Calton
- Celapram
- Celexa
- Celica
- Ciazil
- Cibrom
- Cipram
- Cipramil
- Citacip
- Citalo
- Citalonte
- Citalvir
- Citox
- Claropram
- Feliz
- Genprol
- Humorap
- Lupram
- Norecsero
- Prepram
- Prisdal
- Psiconor
- Ran-Citalo
- Relapaz
- Remicital
- Sepram
- Seregra
- Seropram
- Talam
- Tazen
- Zentius
- Zitolex
Dados da fonte
Farmacocinética
| Variável | Valor | Unidade |
|---|---|---|
| Biodisp. oral | 80 | % |
| Peso Molecular | 324 | daltons |
| Unión proteínas | 80 | % |
| Vd | 12 | l/Kg |
| pKa | 9,8 | - |
| Tmax | 2 - 4 | horas |
| T½ | 35 | horas |
| Índice L/P | 1 - 3 | - |
| Dosis Teórica | 0.024 - 0,048 | mg/Kg/d |
| Dosis Relativa | 3,6 - 18,3 | % |
Rastreabilidade
Bibliografia
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