Leitura clínica
Comentário
A vacina contra a difteria contém toxoide de Corynebacterium diphtheriae. Não é uma vacina de organismos vivos. A vacina contra o tétano contém o toxoide de Clostridium tetani. Não é uma vacina de organismos vivos. O elevado peso molecular de ambos os toxoides (Pappenheimer 1940) dificulta a excreção no leite materno. Diversas sociedades médicas e autores especialistas consideram seguro o uso desta vacina durante a amamentação. (CDC 2023 y 2011, Red Book 2021-2024 p108-9, CAV-AEP 2019, Lawrence 2016 p402, Taylor 2003, Briggs 2015, Sachs 2013, Raney 2012, Chen 2010, WHO 2002) VACINAS E AMAMENTAÇÃO: (RedBook 2021-2024, CDC 2023, 2011 y 2000, Taylor 2019, Lawrence 2016 p402, Sachs 2013, Munoz 2013, Raney 2012, Perin 2012, Gall 2012, Chen 2010, Pisacane 2010, Schmidt 2004, López 2002, Pickering 1998, Pabst 1997, Hahn 1990) As vacinas são compatíveis com a amamentação, tanto as que são microrganismos vivos atenuados como mortos, inativados, formadas por partes ou toxoides deles ou geradas por tecnologia recombinante. Não passam para o leite, salvo a da rubéola, que não costuma infectar o lactente ou o faz de forma leve, e não ocasionam problemas nos lactentes, salvo a da febre amarela em menores de 6 meses. A amamentação pode melhorar a resposta de anticorpos das vacinas e provocar menos efeitos secundários como febre ou anorexia. O pós-parto imediato é o melhor momento para vacinar contra sarampo-rubéola-caxumba e varicela em mulheres que não estivessem imunizadas. As mulheres que amamentam podem e devem ser protegidas com as vacinas recomendadas como os demais adultos. Os lactentes amamentados devem ser imunizados segundo o calendário vacinal correspondente.
Encontrabilidade
Outros nomes e marcas
Sinônimos e grafias 1
- J07AM51
Marcas comerciais na fonte 14
- ADT (Australia, Nueva Zelanda)
- ADT (АДС)
- Clodivac
- DT
- Decavac
- DiTe Booster
- Dif-Tet-All
- Diftavax
- Ditanrix
- Imovax DT
- Td Adsorbed
- Td-Impfstoff
- Td-pur
- Vacuna Doble
Dados da fonte
Farmacocinética
| Variável | Valor | Unidade |
|---|---|---|
| Peso Molecular | Dift: 62.000 / Tet: 150.000 | daltons |
Rastreabilidade
Bibliografia
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