Leitura clínica
Comentário
A vacina da difteria contém o toxoide do Corynebacterium diphtheriae. Não é uma vacina de organismos vivos. Seu elevado peso molecular (Pappenheimer 1940) dificulta a excreção no leite materno. Diversas sociedades médicas e autores especialistas consideram seguro o uso desta vacina durante a amamentação. (CDC 2023 y 2011, Red Book 2021-2024 p108-9, CAV-AEP 2019, Lawrence 2016 p402, Taylor 2003, Briggs 2015, Sachs 2013, Raney 2012, Chen 2010, WHO 2002) VACINAS E AMAMENTAÇÃO: (RedBook 2021-2024, CDC 2023, 2011 y 2000, Taylor 2019, Lawrence 2016 p402, Sachs 2013, Munoz 2013, Raney 2012, Perin 2012, Gall 2012, Chen 2010, Pisacane 2010, Schmidt 2004, López 2002, Pickering 1998, Pabst 1997, Hahn 1990) As vacinas são compatíveis com a amamentação, tanto as que são microrganismos vivos atenuados quanto mortos, inativados ou formadas por partes ou toxoides dos mesmos ou geradas por tecnologia recombinante. Não passam para o leite, salvo a da rubéola, que não costuma infectar o lactente ou o faz de forma leve, e não ocasionam problemas nos lactentes, salvo a da febre amarela em menores de 6 meses. A amamentação pode melhorar a resposta de anticorpos das vacinas e provocar menos efeitos secundários, como febre ou anorexia. O pós-parto imediato é o melhor momento para vacinar contra sarampo-rubéola-caxumba e varicela em mulheres que não estivessem imunizadas. As mulheres que amamentam podem e devem ser protegidas com as vacinas recomendadas como os demais adultos. Os lactentes amamentados devem ser imunizados segundo o calendário vacinal correspondente.
Encontrabilidade
Outros nomes e marcas
Sinônimos e grafias 1
- J07AF01
Marcas comerciais na fonte 6
- AD-M (АД-М)
- Boostrix Polio suspensión inyectable
- Hexyon suspensión inyectable
- Infanrix DTPa-IPV+Hib
- Infanrix hexa
- Infanrix-IPV, suspensión inyectable
Dados da fonte
Farmacocinética
| Variável | Valor | Unidade |
|---|---|---|
| Peso Molecular | 62.000 | daltons |
Rastreabilidade
Bibliografia
- CDC- ACIP. Vaccine Recommendations and Guidelines of the ACIP. Special Situations. Breastfeeding and Vaccination. - 2023 Consultado el 25 de Octubre de 2023 Texto completo (enlace a fuente original)
- CDC - Centers for Disease Control and Prevention. Vaccination Safety for Breastfeeding Mothers. Breastfeeding and Special Circumstances. 2023 Texto completo (enlace a fuente original) Texto completo (en nuestros servidores)
- Zullo F, Di Mascio D, Berghella V. Evidence-based labor management: postpartum care after vaginal delivery (part 6). Am J Obstet Gynecol MFM. 2023 Jul;5(7):100977. Resumen
- (Red Book). AAP. Kimberlin DW, Barnett ED, , Lynfield R, Sawyer MH eds. Red Book: 2021-2024. Report of the Committee on Infectious Diseases. 32th ed. Elk Grove Village, - 2021
- Taylor CM, Shelton CM. Vaccine recommendations in pregnancy and lactation. J Am Pharm Assoc (2003). 2019 Jan - Feb;59(1):137-140. Resumen
- CAV-AEP. Comité asesor de vacunas de la Asociación Española de Pediatría. Lactancia materna y vacunas. None 2019 Texto completo (enlace a fuente original) Texto completo (en nuestros servidores)
- Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Resumen Texto completo (enlace a fuente original) Texto completo (en nuestros servidores)
- Munoz FM. Maternal immunization: an update for pediatricians. Pediatr Ann. 2013 Resumen
- Gall SA. Prevention of pertussis, tetanus, and diphtheria among pregnant, postpartum women, and infants. Clin Obstet Gynecol. 2012 Resumen
- Perin MC, Schlindwein CF, de Moraes-Pinto MI, Simão-Gurge RM, de Mello Almada Mimica AF, Goulart AL, dos Santos AM. Immune response to tetanus booster in infants aged 15 months born prematurely with very low birth weight. Vaccine. 2012 Resumen Texto completo (en nuestros servidores)
- Raney EC, El-Ibiary SY. Immunizations and pregnancy: an update for pharmacists. J Am Pharm Assoc (2003). 2012 Resumen
- CDC. National Center for Immunization and Respiratory Diseases. General recommendations on immunization --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2011 Resumen Texto completo (en nuestros servidores)
- Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Resumen Texto completo (en nuestros servidores)
- Pisacane A, Continisio P, Palma O, Cataldo S, De Michele F, Vairo U. Breastfeeding and risk for fever after immunization. Pediatrics. 2010 Resumen Texto completo (en nuestros servidores)
- Murphy TV, Slade BA, Broder KR, Kretsinger K, Tiwari T, Joyce PM, Iskander JK, Brown K, Moran JS; Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of pertussis, tetanus, and diphtheria among pregnant and postpartum women and their infants recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008 Resumen Texto completo (en nuestros servidores)
- Schmidt JV, Kroger AT, Roy SL. Report from the CDC. Vaccines in women. J Womens Health (Larchmt). 2004 Resumen
- López-Alarcón M, Garza C, Habicht JP, Martínez L, Pegueros V, Villalpando S. Breastfeeding attenuates reductions in energy intake induced by a mild immunologic stimulus represented by DPTH immunization: possible roles of interleukin-1beta, tumor necrosis factor-alpha and leptin. J Nutr. 2002 Resumen Texto completo (en nuestros servidores)
- WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Resumen Texto completo (enlace a fuente original) Texto completo (en nuestros servidores)
- Pickering LK, Granoff DM, Erickson JR, Masor ML, Cordle CT, Schaller JP, Winship TR, Paule CL, Hilty MD. Modulation of the immune system by human milk and infant formula containing nucleotides. Pediatrics. 1998 Feb;101(2):242-9. Resumen
- Pabst HF, Spady DW, Pilarski LM, Carson MM, Beeler JA, Krezolek MP. Differential modulation of the immune response by breast- or formula-feeding of infants. Acta Paediatr. 1997 Resumen
- Hahn-Zoric M, Fulconis F, Minoli I, Moro G, Carlsson B, Böttiger M, Räihä N, Hanson LA. Antibody responses to parenteral and oral vaccines are impaired by conventional and low protein formulas as compared to breast-feeding. Acta Paediatr Scand. 1990 Resumen
- Pappenheimer AM, Lundgren HP, Williams JW. STUDIES ON THE MOLECULAR WEIGHT OF DIPHTHERIA TOXIN, ANTITOXIN, AND THEIR REACTION PRODUCTS. J Exp Med. 1940 Jan 31;71(2):247-62. Resumen Texto completo (enlace a fuente original)