Leitura clínica
Comentário
Derivado dibenzotiazepina. Antipsicótico atípico ou segunda geração, antagonista serotonina dopamina. Indicado no tratamento esquizofrenia transtorno bipolar, outros transtornos psicóticos transtorno limite personalidade. Administração oral em duas doses diárias. Excreta-se em leite materno em quantidade clinicamente não significativa (Yazdani 2018 e 2010, Aydin 2015, Van Boekholt 2015, Rampono 2007, Misri 2006, Lee 2004, Seppala 2004). Não observaram problemas clínicos nem desenvolvimento em bebês que mamam cujas mães tomavam, nem curto nem longo prazo (Levesque 2016, Sharma 2016, Aydin 2015, Van Boekholt 2015, Newport 2009, Rampono 2007, Misri 2006, Gentile 2006, Ritz 2005, Seppala 2004, Lee 2004). Níveis plasmáticos quetiapina em daqueles bebês foram muito baixos (Rampono 2007). Pode produzir-se galactorreia com ou sem aumento da prolactina (Glocker 2021, Suttajit 2013, Mushtaq 2012, Sethi 2010, Gupta 2007, Atmaca 2002). Autores especialistas consideram seguro ou muito provavelmente seguro o uso desta medicação durante amamentação (Hale, Lactmed, Uguz 2021, Teodorescu 2020, Rybakowski 2019, Pacchiarotti 2016, Schaefer 2015, Grover 2005, Larsen 2015, Parikh 2014, Rowe 2013). Pode consultar abaixo a informação deste produto relacionado: Transtorno psicótico materno. Psicose materna, esquizofrenia, transtorno bipolar (Bastante seguro. Efeitos adversos leves ou pouco prováveis. Compatível em determinadas circunstâncias. Acompanhamento recomendado. Leia Comentário.)
Encontrabilidade
Outros nomes e marcas
Sinônimos e grafias 4
- κουετιαπίνη φουμαρική
- Кветиапина Фумарат
- クエチアピンフマル酸塩
- N05AH04
Marcas comerciais na fonte 22
- Atipina
- Biatrix
- Dendritex
- Dominium (Argentina)
- Etiapin
- Ilufren
- Ketilept
- Ketilept (Кетилепт)
- Ketipine
- Ketipinor
- Psicotric
- Qudix
- Quentiax
- Queteper
- Quetex
- Quetiamylan
- Quetiazic
- Quetidin
- Rocoz
- Seroquel
- Tim ASF
- Xeroquel
Dados da fonte
Farmacocinética
| Variável | Valor | Unidade |
|---|---|---|
| Biodisp. oral | 10 | % |
| Peso Molecular | 883 | daltons |
| Unión proteínas | 83 | % |
| Vd | 10 | l/Kg |
| pKa | 15,12 | - |
| Tmax | 1,5 | horas |
| T½ | 7 | horas |
| Índice L/P | 0,3 | - |
| Dosis Teórica | 0,01 - 0,1 | mg/Kg/d |
| Dosis Relativa | 0,1 - 0,43 | % |
Rastreabilidade
Bibliografia
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