Leitura clínica
Comentário
Benzodiazepina de ação curta. Indicações: ansiedade, insônia. Administração oral 1 a 3 vezes ao dia. Excreta-se em leite materno em quantidades não significativas (Nishimura 2021, Lemmer 2007, Summerfield 1985, Whitelaw 1981) e não se observaram problemas em bebês que mamam cujas mães tomavam na dose normal (Nishimura 2021, Kelly 2012, Johnstone 1982, Whitelaw 1981). O uso pontual e em baixa dose de benzodiazepinas é compatível com amamentação (Kelly 2012, Rubin 2004, Iqbal 2002, Hägg 2000, McElhatton 1994, Lee 1993, Kanto 1982). Autores especialistas consideram seguro ou provavelmente seguro o uso desta medicação durante amamentação (Hale, Lactmed, Uguz 2021, Briggs 2015, Schaefer 2015, Nice 2004). Convém escolher benzodiazepinas de duração curta e utilizar dose mínima eficaz (Rowe 2013), especialmente em período neonatal e em caso de prematuridade porque podem acumular-se no bebê que mama durante uso crônico (Sachs 2013). Convém vigiar sonolência e alimentação adequada do bebê que mama. Não se recomenda compartilhar cama com o bebê se estiver tomando este medicamento devido a risco aumentado de asfixia ou morte súbita do bebê que mama (UNICEF 2018, 2017, 2014 e 2013, Landa 2012, ABM 2008, UNICEF 2006).
Encontrabilidade
Outros nomes e marcas
Sinônimos e grafias 6
- Λοραζεπάμη
- لورازيبام
- Лоразепам
- 氯拉西泮
- ロラゼパム
- N05BA06
Marcas comerciais na fonte 68
- Abinol
- Almazine
- Amparax
- Ansilor
- Anta
- Anxira
- Aplacasse
- Aripax
- Ativan
- Calmatron
- Calmese
- Calmogenol
- Control (Italia)
- Donix
- Dorm
- Duralozam
- Emotival
- Idalprem
- Kalmalin
- Larpose
- Latiwen
- Laubeel
- Lonza
- Lora
- Lorabenz
- Lorafen
- Loram
- Loramed
- Lorans
- Loranxil
- Lorapam
- Lorasifar
- Lorax
- Lorazep
- Lorenin
- Lorezan
- Loridem
- Lorivan
- Lorsedal
- Max-Pax
- Merlit
- Microzepam
- Modium
- Nervistop L
- Nifalin
- Novhepar
- Novo-Lorazem
- Nu-Loraz
- Optisedine
- Ora
- Orfidal
- Placinoral
- Razepam
- Sedatival
- Sedazin
- Sedicepan
- Serenase (Bélgica)
- Sidenar
- Somagerol
- Somnium
- Tavor (Alemania, Grecia, Italia)
- Temesta
- Titus
- Tranavan
- Trankilium
- Tranqipam
- Trapax
- Vigiten
Dados da fonte
Farmacocinética
| Variável | Valor | Unidade |
|---|---|---|
| Biodisp. oral | 90 | % |
| Peso Molecular | 321 | daltons |
| Unión proteínas | 85 | % |
| Vd | 1 | l/Kg |
| Tmax | 2 | horas |
| T½ | 12 (10 - 20) | horas |
| Índice L/P | 0,2 - 0,3 | - |
| Dosis Teórica | 0,0003 - 0,002 | mg/Kg/d |
| Dosis Relativa | 1 - 4,3 | % |
| Dosis Rel. Ped. | 0,3 - 0,7 | % |
Rastreabilidade
Bibliografia
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