Leitura clínica
Comentário
Anticorpo monoclonal humanizado IgG1 anti-Imunoglobulina E (IgE). É uma imunoglobulina G (IgG) de enorme peso molecular que se liga com grande afinidade à IgE, bloqueando-a e formando complexos IgG-IgE de tamanho e peso molecular ainda maiores. Indicado na profilaxia da asma grave persistente e no tratamento da urticária crônica. É um produto autorizado em crianças a partir de 6 anos (EMA 2016, Pediamecum 2015) . Administração subcutânea a cada 2 a 4 semanas. Seu peso molecular elevadíssimo explica a passagem ínfima ou nula para o leite materno observada (Saito 2020) , já que moléculas de mais de 500 - 1.000 Da não passam para o leite materno. (Hale, Almas 2016, Anderson 2016) Não foram observados problemas em lactentes de mães tratadas com omalizumab. (Losappio 2020, López 2019, Ensina 2017, González 2017) Por sua natureza proteica, é inativado no trato gastrointestinal, não sendo absorvido (biodisponibilidade oral praticamente nula), o que dificulta ou impede a passagem para o plasma do lactente a partir do leite materno ingerido (Lactmed, Rademaker 2018, Bragnes 2017, Götestam 2016, Witzel 2014, Butler 2014, Mervic 2014) , exceto em prematuros e no período neonatal imediato, nos quais pode haver maior permeabilidade intestinal. Autores especialistas consideram seguro ou muito provavelmente seguro o uso deste e de outros anticorpos monoclonais durante a amamentação. (Hale, Lactmed, Türk 2020, Middleton 2020, Whittam 2019, Matro 2018, Anderson 2018 y 2016, Witzel 2014, Pistilli 2013)
Encontrabilidade
Outros nomes e marcas
Sinônimos e grafias 7
- Olizumab
- أماليزوماب
- Омализумаб
- 奥马珠单抗
- オマリズマブ
- IGE-025; rhuMAb-E25
- R03DX05
Marcas comerciais na fonte 1
- Xolair
Dados da fonte
Farmacocinética
| Variável | Valor | Unidade |
|---|---|---|
| Biodisp. oral | 0 (Subcut: 62) | % |
| Peso Molecular | 149.000 | daltons |
| Vd | 0,08 | l/Kg |
| Tmax | 168 - 192 | horas |
| T½ | 624 | horas |
| Dosis Teórica | 0,0003 -0,001 | mg/Kg/d |
Rastreabilidade
Bibliografia
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- Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consultado el 10 de Abril de 2024 Texto completo (enlace a fuente original)
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