Leitura clínica
Comentário
Antidepressivo ISRS com ações e usos semelhantes aos da fluoxetina. Administração oral em uma dose diária. É excretada no leite materno em quantidade muito pequena, clinicamente insignificante. (Pogliani 2019, Weisskopf 2017, Salazar 2016, Misri 2006 y 2000, Stowe 2000, Ohman 1999, Begg 1999, Spigset 1996) Os níveis plasmáticos nos lactentes cujas mães tomam paroxetina são habitualmente indetectáveis ou muito baixos. (Berle 2004, Hendrick 2001, Misri 2000, Begg 1999, Birnbaum 1999) Não foram observadas repercussões clínicas nem de desenvolvimento a curto ou longo prazo. (Pogliani 2019, Uguz 2019 y 2016, Berle 2004, Merlob 2004, Hendrick 2003, Ohman 1999, Begg 1999) Pode haver problemas transitórios durante o período neonatal imediato, como a síndrome de descontinuação de antidepressivos, em recém-nascidos a termo ou prematuros que nascem com níveis plasmáticos altos porque suas mães tomam paroxetina durante a gravidez. (Hale 2010, Knoppert 2006, Costei 2002, Stiskal 2001, Nordeng 2001) A paroxetina, como outros antidepressivos, pode causar problemas de galactorreia com ou sem hiperprolactinemia. (Bhattacharjee 2021, Mishra 2019, Kumar 2018, Trenque 2011, Chakraborty 2010, Davenport 2002, Morrison 2001, González 2000, Bonin 1997, Egberts 1997) Diversas sociedades médicas e consensos de especialistas consideram seguro o uso desta medicação durante a amamentação. (Hale, Lactmed, Salazar 2016, Uguz 2021, 2019 y 2016, Orsolini 2015, Sriraman 2015, Rowe 2013, Amir 2011, Berle 2011, Patil 2011, Lanza 2009, ABM 2008, Field 2008, Gentile 2005, Weissman 2004, Rubin 2004, Gjerdingen 2003, Wisner 2002, Nordeng 2001) Mulheres com depressão durante a gravidez precisam de mais apoio à amamentação por terem maior risco de problemas e interrupção precoce da amamentação. (Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012) Pode consultar abaixo a informação deste produto relacionado: Depressão Materna (Produto seguro e/ou a amamentação é a melhor opção.)
Encontrabilidade
Outros nomes e marcas
Sinônimos e grafias 8
- Hidrocloruro de paroxetina. Mesilato de paroxetina
- Παροξετίνη
- باروكسيتين
- Пароксетин
- 帕罗西汀
- パロキセチン
- BRL-29060; FG-7051
- N06AB05
Marcas comerciais na fonte 22
- Aipratex
- Apo-Oxpar
- Arapaxel
- Aropax
- Brisdelle
- Casbol
- Daparox
- Deroxat
- Frosinor
- Le You (乐友)
- Motivan
- Paxetil
- Paxil
- Paxil (Паксил)
- Pexeva
- Pondera
- Rexetin (Рексетин)
- Sereupin
- Seroxat
- Seroxat (赛乐特)
- Tagonis
- Xetin
Dados da fonte
Farmacocinética
| Variável | Valor | Unidade |
|---|---|---|
| Biodisp. oral | 100 | % |
| Peso Molecular | 366 | daltons |
| Unión proteínas | 93 - 95 | % |
| Vd | > 1 | l/Kg |
| pKa | 9,8 | - |
| Tmax | 6 - 10 | horas |
| T½ | 15 - 33 | horas |
| Índice L/P | 0,06 - 1,3 | - |
| Dosis Teórica | 0,02 | mg/Kg/d |
| Dosis Relativa | 2 - 5 | % |
Rastreabilidade
Bibliografia
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