Leitura clínica
Comentário
Vitamina B12 existe naturalmente no leite em concentração 1 nanograma/mL (Sauberan 2019; intervalo: 0,3 a 3 ng/mL). Suplementação materna com cianocobalamina apenas aumenta níveis no leite mulheres bem nutridas (Sandberg 1981) mas sim que os melhora na de mulheres baixo nível socioeconômico (Sneed 1981). Concentração colostro é até 28 vezes superior à leite maduro. Necessidades diárias Vitamina B12 são 2,4 microgramas (Sauberan 2019) e aumentam 2,8 microgramas diários durante amamentação. Alimentos ricos vitamina B12 são carnes, vísceras, ovos, lácteos, salmão, sardinhas, amêijoas e cereais enriquecidos. Com dieta variada e equilibrada não se necessitam suplementos vitaminas, mas foi-se observado carência B12 em plasma e leite mulheres com dietas vegetarianas estrictas (veganas), doenças má absorção (p.e: Crohn, doença celíaca), cirurgia bariátrica, mal estado nutricional, anemia perniciosa, nível socioeconômico baixo e em caso catástrofes naturais ou guerras. Há numerosas publicações que demonstram que lactentes destas mães têm alto risco doença por carência vitamina B12 que pode cursar com anemia, atraso crescimento e atraso psicomotor. A "pasteurização Flash" aplicada leite mães HIV + não diminui concentração vitamina B12. Academia Americana Pediatria: medicação usualmente compatível com amamentação (AAP 2001). Listado medicamentos essenciais OMS: compatível com amamentação (WHO 2002) Pode consultar abaixo informação deste produto relacionado: Dietas vegetarianas (Bastante seguro. Efeitos adversos leves ou pouco prováveis. Compatível em determinadas circunstâncias. Acompanhamento recomendado. Leia o Comentário.)
Encontrabilidade
Outros nomes e marcas
Sinônimos e grafias 14
- Adenosilcobalamina
- Cianocobalamina
- Cobamamida
- Cobamin
- Coenzima B12
- Hidroxocobalamina
- Hidroxocobalamina acetato/cloruro/sulfato
- Mecobalamina
- Metilcobalamina
- Κυανοκοβαλαμίνη; Υδροξυκοβαλαμίνη
- كوباماميد; سيانوكوبالامين; هيدروكسوكوبالامين; ميكوبالامي
- Витамины Группы B12; Кобамамид; Цианокобаламин; Гидроксокобаламин; Мекобаламин
- ビタミン; コバマミド; シアノコバラミン; ヒドロキソコバラミン; メコバラミン
- B03BA01; B03BA03; B03BA04; B03BA05; V03AB33
Marcas comerciais na fonte 53
- 102 Plus
- Anemidox
- Bago B1 B6 B12
- Bedoyecta tri
- Bioglobina
- Cocarnit (Кокарнит)
- Cromatonbic B12
- Cyanokit
- Dolo-Tiaminal
- Dorixina B1 B6 B12
- Elevit
- FAB Iron
- Floradix
- Floradix Formula
- Floravit
- Folyoben
- Fortical (México)
- GyneFer
- Hemamina
- Hidroxil B12 B6 B1
- Inzitan
- Isopto B 12
- Megamilbedoce
- Multibionta Complex
- Natalac FeFol
- Nefersil B
- Nervobion
- Neurobion
- Neurocam
- Neuroflax (México)
- Optovite B12
- Pharmaton Matruelle
- Polper Vascular
- Pondusvitam
- Profol (Brasil)
- Propan
- Seidibion Embarazo
- Seidibion Mater preparto, posparto y lactancia
- Seidibion Prime Embarazo
- Suplefol
- Supradyn Forte
- Supradyn Prenatal
- Supradyn Pronatal
- Supravite
- Tiaminal B12
- Tiaminal B12 Trivalente
- Trofalgon
- Tunik B12
- Udamin
- Yectafer Complex
- Yodocefol
- Yoduk Complex
- Yofolvit
Dados da fonte
Farmacocinética
| Variável | Valor | Unidade |
|---|---|---|
| Peso Molecular | 1344 - 2791 | daltons |
| Unión proteínas | Alta - High | % |
| Tmax | 2 - 8 | horas |
| T½ | 144 | horas |
| Índice L/P | 1 | - |
Rastreabilidade
Bibliografia
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